生物化學暨細胞分子生物學科

 師資介紹

黃彥華 主任 (個人專頁請按此連結)

職稱：特聘教授

學歷：國立台灣大學生化科學研究所博士

專長：多能性幹細胞與癌幹細胞之微環境訊息調控機制
           生殖幹細胞、肝癌幹細胞、子宮內膜癌幹細胞

Email：rita1204@tmu.edu.tw

電話：02-2736-1661 分機 3150

研究室網頁：Rita Lab   Rita Blog

 

 

 
經歷：  

2019~present Dean, Office of Research and Development, Taipei Medical University
2019~ CEO/Director, TMU Research Center for Cell Therapy and Regeneration Medicine/GTP Laboratory, Taipei Medical University, Taipei, Taiwan
2016~ present Distinguished Professor, Taipei Medical University, Taipei, Taiwan (Twice awarded)
2016~ present Director, International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
2015~ present Director, TMU Research Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan
2016~ present Director, TMU GTP Laboratory, Taipei Medical University, Taipei, Taiwan
2014~ 2018 Professor and Director, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
2014~ present Committee member of JIRB, Taipei Medical University (TMU-JIRB), Taiwan
2013~ present Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
2010~ present Deputy Director, Center for Teeth Bank and Dental Stem Cell Biotechnology, Taipei Medical University, Taipei, Taiwan
2007~2012 Associate Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
2009 Visiting Scholarship, the Stem Cell Core, NTU Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan
2002~ 2006 Assistant Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
2003~ 2004 Visiting Professor, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan


研究簡介 |  授課科目  |  榮譽與服務  |  研究計畫  |  著作專利


生物化學、生物化學及實驗、生物化學實驗、生物化學整合課程、生物技術、蛋白工程及酵素學、幹細胞與細胞科技、專題討論、組織工程與再生醫學、進階幹細胞與癌幹細胞學、幹細胞與組織再生工程、幹細胞醫學、轉譯醫學、生物化學特論、研究設計、生殖醫學研究、基因醫學等。(本學年主授科目列表)

 

榮譽：更多獎項

年 度

 獎項名稱
2020 National Innovation Award. Taiwan. (2020) 中華民國109 年度國家新創獎精進獎
2019 National Innovation Award. Taiwan. (2019) 中華民國108 年度國家新創獎學研獎
Excellent Teacher Award, Ministry of Education, Taiwan, R.O.C. 中華民國108 年度教育部師鐸獎
Distinguished Professor, Taipei Medical University, Taipei, Taiwan 2019-2022 二度榮獲臺北醫學大學特聘教授
2018 Chief Principle Investigator, Sorafenib-Resistance Hepatocellular Carcinoma Program Project, Ministry of Science Technology (MOST), Executive Yuan, Taiwan. (2018-2021)
科技部整合型計畫總主持人
Faculty Award of Taipei Medical University in Excellence of Teaching, Administration, and Research. (2018, 2013, Twice Awarded) 繼2013年後，於2018再度榮獲臺北醫學大學師鐸獎
2017 Chief Principle Investigator, Regeneration Medicine Technology Development Program Project, Ministry of Science Technology (MOST), Executive Yuan, Taiwan. (2017-2020)
再生醫學科技發展計畫總主持人

2016

 2016 台灣癌症醫學會 董大成博士癌症基礎醫學研究傑出獎(2016 The Outstanding Basic Research Award for Cancer Medicine of Dr. Da-Cheng Tung, The Chinese Oncology Society (COS))
2016 科技部105年度補助大專校院獎勵特殊優秀人才獎勵
2016臺灣女科技人群像介紹
Distinguished Professor, Taipei Medical University, Taipei, Taiwan 2016-2019 臺北醫學大學特聘教授

2015

 2015臺北醫學大學國際頂尖論文獎 (2015 The International Top Journal Research Award of Taipei Medical University)

2015 臺北醫學大學研究論文獎¬—優良獎 (2015 The Excellent Prize Research Award of Taipei Medical University

2015 科技部104年度補助大專校院獎勵特殊優秀人才獎勵

2015 The Prize Oral Award, “Insulin-like Growth Factor I Stimulates Cell Migration Through SDF-1/CXCR4 Regulation in Mouse Germline Stem Cells”, 2015 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan

2015 The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan

2014

2014 The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2014 TSSCR), Taipei, Taiwan

2014 科技部103年度補助大專校院獎勵特殊優秀人才獎勵

2013

2013 臺北醫學大學師鐸獎 (2013 Faculty Award of Taipei Medical University in Excellence of Teaching, Administration, and Research.)

2013 The First Prize Oral Award, “IGF-1R-HIF-2a Signal Loop Supports the
Proliferation and Oct-4 Maintenance of Alkaline Phosphatase Positive Mouse Germline
Stem Cells Under Hypoxia. 2013 TSRM, Annual Meeting of Taiwan Society for Reproductive Medicine

2013 The Prize Poster Award, “Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation” & “Role of IGF-1R Signaling in Oct-4 Maintenance of Alkaline Phosphatase Positive Germline Stem Cells”. 2013 The 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

2013 The Excellent Research Paper Award,” Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation “. 2013 Teachers and Students Joint Academic Research Symposium,Taipei Medical University, Taipei, Taiwan

2013 The Prize Poster Award, “ IGF-IR-HIF-2a Signaling Loop Supports the Cell Proliferation and Oct4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cell. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.

2013 The Prize Poster Award, “ HBx Stimulates the Expression of Stemness-related Properties through SENP1in HBV-related Hepatocellular Carcinomas. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.

2013 臺北醫學大學師鐸獎 (2013 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan)
2012 2012 The Prize Poster Award, “ IL-6 stimulates stemness properties and early recurrence of HCC through IGF-IR activation. 2012 Taiwan Society for Stem Cell Research (2012 TSSCR), Taipei, Taiwan.

2012 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan

2012 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei,
Taiwan

1011學期教學評量績優獎 (生物化學)

1012學期教學評量績優獎 (生物化學實驗)
2011  2011 The Second Prize Oral Award, “ SENP1 Regulates OCT4 Under Hypoxia: Effect of Sumoylation on Protein Stability and Drug Susceptibility of Human Pluripotent Germ Cell Tumors” 2011 International Symposium on Recent Advances in Pluripotent Stem Cells &7th Annual Meeting of Taiwan Society for Stem Cell Research (2011 TSSCR).

2011 The First Prize Oral Award, “Inflammation enhances the transformation of epithelial-like endometrium stem cells and initiates endometriosis”. 2011 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2011 TSRM)

The First Prize Award of Excellent Research, “Role of IL-6-IGF-1R Signaling in Early Recurrence and OCT4/NANOG Expression of HBV-related HCCs”. Taipei Medical University, Taipei, Taiwan

2011 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan 

1001學期教學評量績優獎

1002學期教學評量績優獎
2010 2010 臺北醫學大學第一屆校級優良教師

2010 Prize Poster Award, “Crosstalking of Hypoxia and IGF-1 Signaling in Transformation of Mouse Germline Stem Cells”. The 18th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan

2010 The First Prize Poster Award, “Role of inflammation in transformation of epithelial-like endometrium stem cells and it’s implication on endometriosis”. 2010 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2010 TSRM)

2010 The First Prize Award of Excellent Research, “Role of Inflammation in Transformation of Epithelial-like Endometrium Stem Cells and its Implication on Endometriosis”, Taipei Medical University, Taipei, Taiwan

The Second Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan

2010 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

教學評量優良教師 (醫學系、保健系)

99 學年度提昇課程品質獎勵-全英語授課
醫學系系級醫學系教學優良教師
醫學院院級教學優良教師
第一屆校級教學優良教師
2009 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009) – “ Hypoxia Stress Enhances the IGF-1 Signaling in Pluripotent Mouse Germline Stem Cells” , Taipei, Taiwan (2009 PRSFS)

2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and
Sterility (PRSFS 2009)- “Role of IGF-1/IGF-1R Signaling in Mouse Germline Stem
Cells’ Pluripotency and Tumorigenesis”, Taipei, Taiwan (2009 PRSFS)

2009 Prize Poster Award, “Insulin-like Growth Factor 1 is Required for Pluripotency of
Mouse Spermatogonial Stem Cells”. The 17th Conference of The Chinese Society of
Cell and Molecular Biology, Kaoshung, Taiwan

2009 The First Prize Award of Excellent Research, “Cross-talking of Hypoxia and IGF-1 Signaling in Pluripotent Spermatogonial Stem Cells“, Taipei Medical University, Taipei, Taiwan

2009 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

服務：

校內主管:

生物化學暨細胞分子生物學科 科主任 (2014.02.01~2019.01.31)

生涯發展與就業服務組 組長(~2010.7)

研究發展處研發長 (2019~)

校內服務:

毒物化學物質運作管理委員會委員、教師申訴委員會委員、醫科所所務會議委員、學生申訴評議委員會委員、環保暨安全衛生委員會委員、人力資源規劃暨評議委員會

校外服務:

2020 Member of Committee Board, National Development Fund, Executive Yuan, Taiwan 行政院國家發展基金會審查委員會
2019~ 2022 Member of Director Board, China Development Finacial (Presenter for National Development Fund, Executive Yuan, Taiwan
行政院國家發展基金會法人董事_中華開發金控)
2019~ 2022 Member of Director Board, Eminent Venture Capital Corporation (Presenter for National Development Fund, Executive Yuan, Taiwan
行政院國家發展基金會法人董事_啟航創業投資股份有限公司)
2019~ Committee Member, Cell Therapy Price Evaluation Board, Ministry of Health and Welfare (MOHW), Taiwan
衛福部細胞治療特管辦法定價委員會
2019~ Committee Member, Ministry of Economic (MOE), Taiwan　
經濟部技術處科專委員會
2018 Committee Board, The BioTaiwan Council (BTC) Meeting. Executive Yuan, Taiwan
行政院生物產業諮議委員會 (2018, 2019)
2017~ Reexamination Committee Board Member, Ministry of Science Technology (MOST), Taiwan
科技部生科司計畫複審委員會 (2017, 2018, 2019, 2021)
2016~ 2022 Member of Director Board, TaiGen Biotechnology (Presenter for National Development Fund, Executive Yuan, Taiwan
行政院國家發展基金會法人董事_太景醫藥研發控股股份有限公司)
2015~ 2018 Committee Member, Regeneration Medicine and Cell Therapy Development Board, Ministry of Health and Welfare (MOHW), Taiwan
衛福部再生醫學與細胞治療諮議會
2014~ 2018 Committee Member of Regeneration Medicine Board, Food and Drug Administration (TFDA), Taiwan
衛福部食品藥物管理署再生醫學諮議會

國內及國際期刊審查委員:

2021~present Associate Editor, Frontiers of Cell and Developmental Biology (IF 5.201)
2020 Guest Editor, Frontiers of Cell and Developmental Biology (IF 5.201)
2018~ present Member of Executive Director Board, Taiwan Association for Cell Therapy (TACT), Taiwan
2017~ present Member of Executive Director Board, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
2014~ 2017 Member of Director Board, Taiwan Association for Cell Therapy (TACT), Taiwan
2014~ 2016 Member of Director Board, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
2011~ 2013 Secretary General, Taiwan Society for Stem Cell Research (TSSCR), Taiwan

 

更多研究計畫

計畫編號

計畫名稱

輔助機關

總核定金額

執行起始日

執行終止日
MOST105-2628-B-038-008MY3(1-3) 探討HBx蛋白與雄性激素受體調控蛋白小泛素化SUMO修飾酵素SENP1與B型肝炎誘發肝癌細胞表現癌幹細胞特性之分子機制與臨床意義 (1/3) 科技部 1,860,000
2016/8/1
 2017/7/31
MOST104-2321-B-038-003 探討萬能分化性、再程序化與生殖系細胞分化之分子基礎－探討幹細胞萬能分化性表現於胚胎期萬能性幹細胞與體組織癌細胞之不同調控機制與其在人類疾病之臨床意義-- 微環境生長因子/細胞素訊息、細胞外基質、與表基因體調節網之交互作用(子計畫三)(2/2) 科技部 2,800,000
2015/10/1
 2016/9/30
NSC102-2628-B-038-008-MY3(3-3) 低氧環境下HBX與介白素IL-6調控SUMO加工酵素SENP1與誘導HBV相關肝癌細胞表現幹細胞特性及其臨床意義(3/3) 科技部 1,660,000
2015/8/1
 2016/7/31
TMU-T104-06 幹細胞基礎研究與前臨床動物試驗 臺北醫學大學 1,200,000 2015/8/1 2016/7/31
104TMU-TMUH-04 探討缺氧環境中透過Hif-2α支配的Igf-1r—Cxcr4訊號迴路調控小鼠生殖系幹細胞爬行作用機制 臺北醫學大學附設醫院 500,000 2015/6/1 2016/5/31
A-104-011 StemBios幹細胞研究計畫 StemBios Technologies, Inc. 8,000,000 2014/12/15 2017/12/14
MOST103-2321-B-038-011 探討萬能分化性、再程序化與生殖系細胞分化之分子基礎－探討幹細胞萬能分化性表現於胚胎期萬能性幹細胞與體組織癌細胞之不同調控機制與其在人類疾病之臨床意義-- 微環境生長因子/細胞素訊息、細胞外基質、與表基因體 科技部 2,800,000 2014/10/1 2015/9/30
A-103-057 StemBios幹細胞混和複合式材料於皮膚傷口修復能力之動物模式評估研究計畫 StemBios Technologies, Inc. 3,000,000 2014/9/1 2015/8/31
NSC102-2628-B-038-008-MY3(2-3) 低氧環境下HBX與介白素IL-6調控SUMO加工酵素SENP1與誘導HBV相關肝癌細胞表現幹細胞特性及其臨床意義(2/3) 行政院國家科學委員會 1,660,000 2014/8/1 2015/7/31
103TMU-TMUH-05 探討胞外基質Laminin與類胰島素生長因子-1於精原幹細胞自我更新之訊息傳遞機制 臺北醫學大學附設醫院 450,000 2014/6/1 2015/5/31

103TMU-WFH-01-2

小分子團水對降低血脂膽固醇之動物模式與其在粥狀動脈硬化症之臨床意義探討

北醫大/萬芳醫院

 500,000 2014/6/1 2015/5/31
NSC 102-2321-B-038-001 從多能性幹細胞到生殖細胞-微環境訊息傳遞網對多功能性精原幹細胞自我更新與遷移之調控與人類多功能性幹細胞分化為配子的可能性--子計畫三(3/3) 行政院國家科學委員會

2,801,000

2013/10/1

2014/9/30

NSC 102-2628-B-038-008-MY3(1-3)

低氧環境下HBX與介白素IL-6調控SUMO加工酵素SENP1與誘導HBV相關肝癌細胞表現幹細胞特性及其臨床意義(1/3)

行政院國家科學委員會

1,660,000

2013/8/1

2014/7/31

A-102-023

StemBios幹細胞於異體移植之動物模式前臨床試驗安全性與功能性評估

StemBios Technologies, Inc.

2,000,000

2013/6/1

2014/5/31

102TMU-TMUH-13

子宮內膜異位症中乙式轉形生長因子在調控OCT4表現及上皮細胞/間葉細胞間轉型之角色探討

北醫大/附設醫院

 450,000

2013/6/1

2014/5/31

NSC 101-2321-B-038-001

從多能性幹細胞到生殖細胞-微環境訊息傳遞網對多功能性精原幹細胞自我更新與遷移之調控與人類多功能性幹細胞分化為配子的可能性--子計畫三(2/3)

行政院國家科學委員會

2,818,000

2012/10/1

2013/9/30

NSC 99-2628-B-038-009-MY3(3-3)

探討類胰島素訊息與微環境因子(低氧與發炎)之訊息傳導迴路於癌幹細胞形成的角色與臨床分子標靶治療之意義(精原幹細胞模式)

行政院國家科學委員會

1,340,000

2012/8/1

2013/7/31

NSC 100-2321-B-038-003

從多能性幹細胞到生殖細胞-微環境訊息傳遞網對多功能性精原幹細胞自我更新與遷移之調控與人類多功能性幹細胞分化為配子的可能性--子計畫三(1-3)

行政院國家科學委員會

2,803,000

2011/10/1

2012/9/30

NSC 99-2628-B-038-009-MY3(2-3)

探討類胰島素訊息與微環境因子(低氧與發炎)之訊息傳導迴路於癌幹細胞形成的角色與臨床分子標靶治療之意義(精原幹細胞模式)

行政院國家科學委員會

1,340,000

2011/8/1

2012/7/31

100TMU-TMUH-13

發炎細胞激素與子宮內膜幹細胞於子宮內膜異位症所扮演的角色與其臨床意義

北醫大/附設醫院

 500,000

2011/4/1

2012/3/31

NSC 99-3111-B-038-001

人類胚胎幹細胞與生殖腺幹細胞發育為生殖細胞過程中之基因轉殖、分化與後生調節(延續計畫)-以無血清之細胞培養模式探討調控精原幹細胞自我更新與命運程式再設定的可能因子以及其誘導人類胚胎幹細胞分化為精子的可能性(子計畫二)

行政院國家科學委員會

2,000,000

2010/12/1

2011/9/30

NSC 99-2628-B-038-009-MY3(1-3)

探討類胰島素訊息與微環境因子(低氧與發炎)之訊息傳導迴路於癌幹細胞形成的角色與臨床分子標靶治療之意義(精原幹細胞模式)

行政院國家科學委員會

1,300,000

2010/8/1

2011/7/31

NSC 98-3111-B-038-001

人類胚胎幹細胞與生殖腺幹細胞發育為生殖細胞過程中之基因轉殖、分化與後生調節－子計畫二：以無血清之細胞培養模式探討調控精原幹細胞自我更新與命運程式再設定的可能因子以及其誘導人類胚胎幹細胞分化為精子的可能

行政院國家科學委員會

2,617,000

2009/12/1

2010/11/30

 

專利

1.林泰元、陳耀昌、侯勝茂、嚴孟祿、黃彥華、吳孟學 (2013/12) 新發明I419971號: 一種成體幹細胞之組織分解、細胞黏附與萃取暨培養技術
2.林泰元、陳耀昌、黃彥華、吳孟學、區慶建 (2013/09) 新型第M462274號: 一種可由特定組織中取得成體幹細胞以製成生物製劑系統


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