生物化學暨細胞分子生物學科



Rita Yen-Hua Huang, PhD

 (Personal web page)

 

Job Title: Director
Distinguished Professor
Education: PhD National Taiwan University, Biochemistry
Specialty & Expertise: Microenvironment signal regulatory mechanism of Pluripotent stem cells and cancer stem cells, Germline stem cells, Liver cancer stem cells, Endometrial cancer stem cells
Email: rita1204@tmu.edu.tw
Phone: (+886)2-2736-1661 Ext 3150
Web Page: Rita Lab   Rita Blog


Professional Experience


2010~now

Deputy Director, Center for Teeth Bank and Dental Stem Cell Biotechnology, Taipei Medical University, Taipei, Taiwan

2011~2013

Secretary General, Taiwan Society for Stem Cell Research (TSSCR), Taiwan

2014~now

Professor and Director, Department of Biochemistry and Molecular Cell Biology,Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Member of Director Board, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
Member of Director Board, Taiwan Association for Cell Therapy (TACT)
Committee member of JIRB, Taipei Medical University (TMU-JIRB), Taiwan
Committee member of Regeneration Medicine Board, Food and Drug Administration, Taiwan

2015~now

Director, TMU Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan
Committee Member of Regeneration Medicine and Cell Therapy Development Board, Ministry of Health and Welfare

2016~now

Director, TMU GTP Laboratory, Taipei Medical University, Taipei, Taiwan

Distinguished Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan



 | Research Interests |  Honor  |  Grant  | Publication | 


 

Honor(more...)

2016

2016 The Outstanding Basic Research Award for Cancer Medicine of Dr. Da-Cheng Tung, The Chinese Oncology Society (COS)

2016 Ministry of Science and Technology 105 annual subsidy college special award of outstanding talents

2016 Introduction to Female Scientists in Taiwan

2016 The Prize Poster Award, “Niche ECM Laminin Mediates the Expressions of Pluripotent Transcription Factor Oct4 through IGF-IR- HIF-2α- CD49f Circuit Loop in Mouse Germline Stem Cells” 2016 Taiwan Society for Stem Cell Research (2016 TSSCR), Taipei, Taiwan

2015

2015 The International Top Journal Research Award of Taipei Medical University

2015 The Excellent Prize Research Award of Taipei Medical University

2015 Ministry of Science and Technology 104 annual subsidy college special award of outstanding talents

2015 The Prize Oral Award,
Insulin-like Growth Factor I Stimulates Cell Migration Through SDF-1/CXCR4 Regulation in Mouse Germline Stem Cells, 2015 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan

2015 The Prize Poster Award,
Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells, 2014 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan

2014

2014 The Prize Poster Award, Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells, 2014 Taiwan Society For Stem Cell Research (2014 TSSCR), Taipei, Taiwan

2014 Ministry of Science and Technology 103 annual subsidy college special award of outstanding talents

2013

2013 Faculty Award of Taipei Medical University in Excellence of Teaching, Administration, and Research.

2013 The First Prize Oral Award, IGF-1R-HIF-2a Signal Loop Supports the
Proliferation and Oct-4 Maintenance of Alkaline Phosphatase Positive Mouse Germline
Stem Cells Under Hypoxia. 2013 TSRM, Annual Meeting of Taiwan Society for Reproductive Medicine

2013 The Prize Poster Award, Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation & Role of IGF-1R Signaling in Oct-4 Maintenance of Alkaline Phosphatase Positive Germline Stem Cells. 2013 The 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

2013 The Excellent Research Paper Award, Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation . 2013 Teachers and Students Joint Academic Research Symposium,Taipei Medical University, Taipei, Taiwan

2013 The Prize Poster Award, IGF-IR-HIF-2a Signaling Loop Supports the Cell Proliferation and Oct4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cell. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.

2013 The Prize Poster Award, HBx Stimulates the Expression of Stemness-related Properties through SENP1in HBV-related Hepatocellular Carcinomas. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.

2013 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2012

2012 The Prize Poster Award, IL-6 stimulates stemness properties and early recurrence of HCC through IGF-IR activation. 2012 Taiwan Society for Stem Cell Research (2012 TSSCR), Taipei, Taiwan.

2012 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan

2012 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei,
Taiwan

1011 Teaching excellence (Biochemistry)

1012 Teaching excellence (Biochemistry Experiment)

2011

 2011 The Second Prize Oral Award, SENP1 Regulates OCT4 Under Hypoxia: Effect of Sumoylation on Protein Stability and Drug Susceptibility of Human Pluripotent Germ Cell Tumors 2011 International Symposium on Recent Advances in Pluripotent Stem Cells &7th Annual Meeting of Taiwan Society for Stem Cell Research (2011 TSSCR).

2011 The First Prize Oral Award,
Inflammation enhances the transformation of epithelial-like endometrium stem cells and initiates endometriosis. 2011 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2011 TSRM)

The First Prize Award of Excellent Research,
Role of IL-6-IGF-1R Signaling in Early Recurrence and OCT4/NANOG Expression of HBV-related HCCs. Taipei Medical University, Taipei, Taiwan

2011 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan 

1001 Teaching excellence

1002 Teaching excellence

2010

2010 The most excellent teacher of TMU

2010 Prize Poster Award,
Crosstalking of Hypoxia and IGF-1 Signaling in Transformation of Mouse Germline Stem Cells. The 18th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan

2010 The First Prize Poster Award,
Role of inflammation in transformation of epithelial-like endometrium stem cells and its implication on endometriosis. 2010 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2010 TSRM)

2010 The First Prize Award of Excellent Research,
Role of Inflammation in Transformation of Epithelial-like Endometrium Stem Cells and its Implication on Endometriosis, Taipei Medical University, Taipei, Taiwan

The Second Prize Award of Excellent Research,
IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells, Taipei Medical University, Taipei, Taiwan

2010 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

2009

2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009) – “ Hypoxia Stress Enhances the IGF-1 Signaling in Pluripotent Mouse Germline Stem Cells , Taipei, Taiwan (2009 PRSFS)

2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and
Sterility (PRSFS 2009)-
Role of IGF-1/IGF-1R Signaling in Mouse Germline Stem
Cells
Pluripotency and Tumorigenesis, Taipei, Taiwan (2009 PRSFS)

2009 Prize Poster Award,
Insulin-like Growth Factor 1 is Required for Pluripotency of
Mouse Spermatogonial Stem Cells
. The 17th Conference of The Chinese Society of
Cell and Molecular Biology, Kaoshung, Taiwan

2009 The First Prize Award of Excellent Research,
Cross-talking of Hypoxia and IGF-1 Signaling in Pluripotent Spermatogonial Stem Cells, Taipei Medical University, Taipei, Taiwan

2009 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan

 

Journal Review Committee:

American Journal of Physiology Endocrinology and Metabolism

Electronic Journal of Biotechnology

Fertility & Sterility

BMC Developmental Biology

Adaptive Medicine

 

 

Grant  (more...)

Grant Number

Project Topic

Sponsor

NTD

Period from

to

MOST105-2628-B- 038-008MY3(1-3)

Role of HBx and androgen receptor in regulating SENP1/stemessrelated
properties in HBV-related HCC and its clinical impact

Ministry of Science and Technology

1,860,000

2016/8/1

2017/7/31

MOST104-2321- B-038-003

Differential machinery of pluripotency regulation in stem cells in embryonic stage and somatic cancers and its clinical implications in human diseases --crosstalk among niche growth factor/cytokine signaling, extracellular matrix, and epigenetic networks. (2/2)

Ministry of Science and Technology

2,800,000

2015/10/1

2016/9/30

NSC102-2628-B- 038-008-MY3(3-3)

Role of HBX and IL-6 in regulating SENP1 / stemness properties of HBV-related HCC under hypoxia and its clinical implication

Ministry of Science and Technology

1,660,000

2015/8/1

2016/7/31

TMU-T104-06

幹細胞基礎研究與前臨床動物試驗

Taipei Medical University

1,200,000

2015/8/1

2016/7/31

104TMU-TMUH-04

Igf-1rCxcr4 signal loop regulates cell migration through Hif-2α in mouse germline stem cells under hypoxia

TMU Hospital

500,000

2015/6/1

2016/5/31

A-104-011

StemBios幹細胞研究計畫

StemBios Technologies, Inc.

8,000,000

2014/12/15

2017/12/14

MOST103-2321-B- 038-011

Differential machinery of pluripotency regulation in stem cells in embryonic stage and somatic cancers and its clinical implications in human diseases --crosstalk among niche growth
factor/cytokine signaling, extracellular matrix, and epigenetic networks. (1/2)

StemBios Technologies, Inc.

2,800,000

2014/10/1

2015/9/30

A-103-057

StemBios幹細胞混和複合式材料於皮膚傷口修復能力之動物模式評估研究計畫

StemBios Technologies, Inc.

3,000,000

2014/9/1

2015/8/31

NSC102-2628-B- 038- 008-MY3(2-3)

Role of HBX and IL-6 in regulating SENP1 / stemness properties of HBV-related HCC under hypoxia and its clinical implication

Ministry of Science and Technology

1,660,000

2014/8/1

2015/7/31

103TMU-TMUH-05

The mechanism of extracellular matrix (laminin) and insulin-like growth factor-1(IGF-1) in self-renewal signaling of mouse germline stem cells

TMU Hospital

450,000

2014/6/1

2015/5/31

103TMU-WFH-01-2

Effect of Au nano particle-teated (Au-NT) water in reducing plasma cholesterol using animal model and its clinical implications in atherosclerosisi

TMU/Wan Fang Hospital

500,000

2014/6/1

2015/5/31

NSC 102-2321-B- 038-001

Niche signaling networks in self-renewal and migration of pluripotent germline stem cells and its implication for germline differentiation in human pluripotent stem cells. (3/3)

Ministry of Science and Technology

2,801,000

2013/10/1

2014/9/30

NSC 102-2628-B-038- 008-MY3(1-3)

Role of HBX and IL-6 in regulating SENP1 / stemness properties of HBV-related HCC under hypoxia and its clinical implication

Ministry of Science and Technology

1,660,000

2013/8/1

2014/7/31

A-102-023

StemBios幹細胞於異體移植之動物模式前臨床試驗安全性與功能性評估

StemBios Technologies, Inc.

2,000,000

2013/6/1

2014/5/31

102TMU-TMUH-13

The role of TGF-B1 in OCT4 expression and epithelial-mesenchymal transition (EMT) in endometriosis

TMU/TMU Hospital

450,000

2013/6/1

2014/5/31

NSC 101-2321-B- 038-001

Niche signaling networks in self-renewal and migration of pluripotent germline stem cells and its implication for germline differentiation in human pluripotent stem cells. (2/3)

Ministry of Science and Technology

2,818,000

2012/10/1

2013/9/30

NSC 99-2628-B- 038- 009-MY3(3-3)

Circuits of IGF-1R and Niche Signaling (Hypoxia/Inflammation) in Stem Cell Transformation and its Clinical Implication of Molecular Target Therapy (Model of Germline Stem Cells)

Ministry of Science and Technology

1,340,000

2012/8/1

2013/7/31

NSC 100-2321-B- 038-003

Niche signaling networks in self-renewal and migration of pluripotent germline stem cells and its implication for germline differentiation in human pluripotent stem cells. (1/3)

Ministry of Science and Technology

2,803,000

2011/10/1

2012/9/30

NSC 99-2628-B-038- 009- MY3(2-3)

Circuits of IGF-1R and Niche Signaling (Hypoxia/Inflammation) in Stem Cell Transformation and its Clinical Implication of Molecular Target Therapy (Model of Germline Stem Cells)

Ministry of Science and Technology

1,340,000

2011/8/1

2012/7/31

100TMU-TMUH-13

Role of inflammatory cytokines and endometrium stem cells in endomatriosis and clincial implication

TMU/TMU Hospital

500,000

2011/4/1

2012/3/31

NSC 99-3111-B- 038-001

Characterization of the self-renewal/reprogramming factors of human/mouse germ line stem cells in

Ministry of Science and Technology

2,000,000

2010/12/1

2011/9/30

NSC 99-2628-B- 038- 009-MY3(1-3)

serum-free culture system and its induction effect on human embryonic stem cells to sperm (Extension proposal)

Ministry of Science and Technology

1,300,000

2010/8/1

2011/7/31

NSC 98-3111-B-038-001

Characterization of the self-renewal/reprogramming factors of human/mouse germ line stem cells in

Ministry of Science and Technology

2,617,000

2009/12/1

2010/11/30

 

Department of Biochemistry and Molecular Cell Biology  |  School of Medicine  |  TMU