 |
Isabel, I-Lin Tsai, PhD |
| Job Title: | Assistant Professor |
| Education: | PhD, National Taiwan University, School of Pharmacy |
|
|
Chromatography-mass spectrometry, Pharmaceutical analysis, Metabolomics, Proteomics |
| Email: | isabel10@tmu.edu.tw |
| Phone: | (+886)2-2736-1661 Ext 3157 |
| Research interests | Grants | Publucation |
(1) Developing sensitive and accurate chromatography-mass spectrometry methods for qualitative and quantitative determination of toxic compounds and drugs in food or biological specimens.
(2) Translational metabolomics: Using chromatography-mass spectrometry based platforms to analyze metabolites in biological samples. Investigating the dynamic changes of metabolites or metabolic profiling related to disease.
(3) Proteomics: Applying proteomics workflow for autoantibody biomarkers investigation.
Grants
|
Grant Number |
Project Topic |
Sponsor |
NTD |
Period from |
to |
|
MOST105-2320-
B-038-066 |
創新高效率免疫球蛋白G分析技術應用於胰臟疾病自體抗體生物標記開發 |
Ministry of
Science and Technology |
900,000 |
2016/8/1 |
2017/7/31 |
|
TMU104-AE1-B21 |
新聘教師研究補助 |
Taipei Medical
University |
1,000,000 |
2016/4/1 |
2017/3/31 |
Publications
1. Chen GY, Liao HW, Tsai IL,
Tseng YJ, Kuo CH*. 2015, Using the Matrix-Induced Ion
Suppression Method for Concentration Normalization in
Cellular Metabolomics Studies. Analytical Chemistry (SCI).
87(19):9731-9739.
2. Chen GY, Liao HW, Tseng YJ,
Tsai IL, Kuo CH*. 2015, A
matrix-induced ion suppression method to normalize
concentration in urinary metabolomics studies using flow
injection analysis electrospray ionization mass
spectrometry. Analytica Chimica Acta (SCI). 864: 21-29.
3. Chepyala D, Tsai IL,
Sun HY, Lin SW, Kuo CH*. 2015, Development and validation of
a high-performance liquid chromatography-fluorescence
detection method for the accurate quantification of colistin
in human plasma. Journal of Chromatography B (SCI). 980:
48-54.
4. Liao HW, Chen GY, Wu MS, Liao WC,
Tsai IL, Kuo CH*. 2015,
Quantification of endogenous metabolites by the postcolumn
infused-internal standard method combined with matrix
normalization factor in liquid chromatography-electrospray
ionization tandem mass spectrometry. Journal of
Chromatography A (SCI). 1375: 62-68.
5. Liu HY, Hwang TJ, Tsai IL,
Kuo CH*. 2015, Use of high conductivity sample solution with
sweeping-micellar electrokinetic chromatography for trace
level quantification of paliperidone in human plasma.
Electrophoresis. 36(4): 534-542.
6. Liao HW, Tsai IL,
Chen GY, Yen-Shen Lu, Ching-Hung Lin, Kuo CH*. 2014,
Quantification of target analytes in various biofluids using
a postcolumn infused-internal standard method combined with
matrix normalization factors in liquid
chromatography-electrospray ionization mass spectrometry.
Journal of Chromatography A (SCI). 1358: 85-92.
7. Liao HW, Chen GY, Tsai IL,
Kuo CH*. 2014, Using a postcolumn-infused internal standard
for correcting the matrix effects of urine specimens in
liquid chromatography–electrospray ionization mass
spectrometry. Journal of Chromatography A (SCI). 1327:
97-104.
8. Tsai IL,
Weng TI, Tseng YJ, Tan KL, Sun HJ, Kuo CH*. 2013, Screening
and confirmation of 62 drugs of abuse and metabolites in
urine by ultra-high-performance liquid chromatography–quadrupole
time-of-flight mass spectrometry. Journal of Analytical
Toxicology (SCI). 37(9):642-651.
9. Tsai IL,
Sun HY, Chen GY, Lin SW, Kuo CH*. 2013, Simultaneous
quantification of antimicrobial agents for
multidrug-resistant bacterial infections in human plasma by
ultra-high pressure liquid chromatography-tandem mass
spectrometry. Talanta (SCI). 116: 593-603.
10. Tsai IL,
Kuo TC, Ho TJ, Harn YC, Wang SY, Fu WM, Kuo CH*, Tseng YJ*.
2013, Metabolomic dynamic analysis of hypoxia in MDA-MB-231
and the comparison with inferred metabolites from
transcriptomics data. Cancers. 5: 491-510.
11. Tsai DM, Kang JJ, Lee SS, Wang SY,
Tsai IL, Chen GY, Liao HW, Li WC,
Kuo CH, Tseng YJ*. 2013, Metabolomic analysis of complex
Chinese remedies: examples of induced nephrotoxicity in the
mouse from a series of remedies containing aristolochic
acid. Evidence-Based Complementary and Alternative Medicine
(SCI). Volume 2013, Article ID 263757.
12. Liao HW, Tsai IL,
Chen GY, Kuo CT, Wei MF, Hwang TJ, Chen WJ, Shen LJ, Kuo
CH*. 2013, Simultaneous detection of single nucleotide
polymorphism and copy number variation of CYP2D6 by
multiplex PCR combined with capillary electrophoresis.
Analytica Chimica Acta (SCI). 763 (6): 67–75.
13. Tsai IL,
Liu HY, Kuo PH, Wang JY, Shen LJ, Kuo CH*, 2011,
Quantitative determination of isoniazid in biological
samples by Cation Selective Exhaustive Injection-Sweeping-Micellar
Electrokinetic Chromatography. Analytical and Bioanalytical
Chemistry (SCI), 401 (7): 2205-2214.
14. Wu WC, Tsai IL,
Sun SW, Kuo CH*, 2011, Using sweeping-micellar
electrokinetic chromatography to determine melamine in food.
Food Chemistry (SCI), 128:783-789.
15. Chiang PC, Lin SC, Pan SL, Kuo CH,
Tsai IL, Kuo MT, Wen WC, Chen P, Guh
JH*. 2010, Antroquinonol displays anticancer potential
against human hepatocellular carcinoma cells: A crucial role
of AMPK and mTor pathways, Biochemical Pharmacology (SCI),
79(2): 162-171.
16. Kuo CH*, Lee CW, Lin SC,
Tsai IL, Lee SS, Tseng YJ, Kang JJ, Peng FC,
Li WC. 2010, Rapid determination of aristolochic acids I and
II in herbal products and biological samples by UHPLC-MS/MS,
Talanta (SCI), 80: 1672-1680.
17. Tsai IL,
Sun SW, Liao HW, Lin SC, Kuo CH*. 2009, Rapid analysis of
melamine in infant formula by sweeping-micellar
electrokinetic chromatography, Journal of Chromatography A
(SCI), 1216: 8296-8303.
18. Tsai IL,
Wu L FL, Gau CS, Kuo CH*. 2009, Method development for the
determination of teicoplanin in patient serum by solid phase
extraction and micellar electrokinetic chromatography,
Talanta (SCI), 77: 1208-1216.
Conferences
1. Tsai IL,
Chang YT, Chang MC, Ferng C, Shih HC, Kuo YP, Chen CH*,
Optimization and validation of human immunoglobulin G
purification process for label-free proteomics study:
application to IgG peptide biomarkers investigation for
autoimmune disease. 6th Asia Oceania Mass Spectrometry
Conference, 2015 (Oral presentation).
2. Tsai IL,
Sun HY, Lin SW, Kuo CH*, Simultaneous quantification of
antimicrobial agents for multidrug-resistant bacterial
infections in human plasma by ultra-high pressure liquid
chromatography-tandem mass spectrometry. 4th Asia Oceania
Mass Spectrometry Conference & 10th Taiwan Society for Mass
Spectrometry Annual Conference, 2013.
3. Tsai IL,
Liu HY, Kuo PH, Wang JY, Shen LJ, Kuo CH*, Quantitative
determination of isoniazid in biological samples by Cation
Selective Exhaustive Injection-Sweeping-Micellar
Electrokinetic Chromatography, Joint Congress 2011- GC X GC,
MSB 2011, ISCC. 2011.
4. Tsai IL,
Kuo CH*, Comprehensive screening of forensic drugs by high
performance liquid chromatography coupled with time of
flight mass spectrometry, The 7th Taiwan Society for Mass
Spectrometry Annual Conference, 2010.
5. Tsai IL,
Sun SW, Liao HW, Lin SC, Kuo CH*, Rapid analysis of melamine
in infant formula by sweeping-micellar electrokinetic
chromatography, Micro scale bioseparations (MSB), 2009.
6. Tsai IL, Wu
L FL, Gau CS, Kuo CH*, Method development for the
determination of teicoplanin in patient serum by solid phase
extraction and micellar electrokinetic chromatography, 12th
Internatioinal Meeting on Recent Developments in
Pharmaceutical Analysis, 2007.